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Chemical structure of Thaimine pyrophosphate |
3D representation (S=yellow N=blue C=gray) |
Vitamin B1 Dependence: Humans do not synthesize Thiamine and therefore require its intake as part of the diet. Thiamine is one of the (many) B types typically called vitamin B1. You may read much more about this and issues regarding its synthesis and deficiencies here.
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TPP provides a mechanism to handle C-C bond formations and cleavages at bonds adjacent to a ketone - So long as there is an alcohol or organic acid on that adjacent carbon
Notice the similarities to the enzyme catalyzed reaction where LYS form a covalent intermediate with the substrate. - They BOTH put a =N+ at the SAME position relative to the C-C bond that is cleaved or formed.
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SOME ENZYMES USING THIS COFACTOR |
| pyruvate decarboxylase (key enzyme in yeast for "bread rising" and "beer making") - more about this enzme in module 6 | |
| pyruvate dehydrogenase (key transition enzyme between glycolysis and the Krebs cycle) - more about this enzyme in module 6 | |
| transketolase | |
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