cofactors and Chemistry

Coenzyme Q

Chemical structure of Coenzyme Q 3D representation

Coenzyme Q (ubiquinone) is part of the electron transport pathway of oxidative phosphorylation as well as that of photosynthesis. It is a membrane soluble cofactor that can take up 1 or 2 electrons as well as an appropriate number of protons. In the oxidative phophorylation pathway it is the electron tranporter immediately following "complex I" or "complex II"

You can buy a version of this at the grocery store - usually labeled as "Q10". It is sold as an aid for converting energy more efficiently. It's not a vitamin in the classic sense - we do synthesize it. A reasonable diet shoud also provide suffieient amounts as well. There are, of course, cases where genetic defects in the enzymes required for synthesis CoQ require an external supplementary source.

SOME ENZYMES USING THIS COFACTOR
photosynthetic reaction center A free cofactor (not part of any enzyme essential for transfer of electrons in photosynthesis (not part of this course)
MitochondriaA free cofactor (not part of any enzyme essential for transfer of electrons in oxidative phosphorylation. we will learn more about this in module 7.