Animation of Hemoglobin Molecule.

T state = Oxygen is NOT bound to the heme Picture morphs ro R state with oxygen bound and then snaps to T state again. Notice: As the His ligated to the Fe is shifted it tkes the entire helix that it is part of with it. As a result the amino acid at the subunit interface must shift positions. This is an ionic interaction between an ARG and a GLU in the "T" state, but inthe "R" state these two amino acids are a long distance apart.
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