
Aerobic GLucose Metabolism
Objectives Module 7/h1>
- How oxidative glucose metabolism compares to the non-oxidative system from the previous module (in terms of the amount of ATP Produced per glucose)
- The complete oxidation of glucose is separate from the reduction of oxygen (O2)...
- What is the primary connection between these systems? or How are the citric acid cycle and the oxidative phosphorylation pathway connected
- As with the previous module associate the 5 basic chemistries with those of the citric acid cycle (note that several enzymes in the citric acid cycle combine more than one type of chemistry on to a single active site).
- How oxidation of carbon is connected to the redction of O2.
- How ATP synthesis is connected to O2 reduction even though ATP synthesis in not redox reaction.
- Thermodynamics of redox reactions and connection to H+ grandient production.
- Thermodynamics of H+ grandient release connections to ATP synthesis.
- The combined systems of citric acid cycle and oxidative phosphorylation use many minerals and vitamin derived cofactors. Look to see where and how they are used.
- iron
- magnesium
- thiamine (vitamin B1) used as the cofactor thiamine pyrophosphate (TPP)
- riboflavin (vitamin B2) used as the cofactor flavin adenine dinucleotide (FAD)
- niacin used as the cosubstrate nicotinamide adenine dinucleotide (NAD+)
- lipoic acid used as the cofactor lipoic acid
- pantothenic acid (vitamin B3) used as part of Coenzyme A